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2 edition of physiological significance of transferrin microheterogeneity found in the catalog.

physiological significance of transferrin microheterogeneity

Gerardus de Jong

physiological significance of transferrin microheterogeneity

an interpretation of the role of N-linked glycans in transferrin and iron metabolism ...Proeefschrift ter verkrijging van de graad van doctor... 1993 ...

by Gerardus de Jong

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  • 23 Currently reading

Published by [Department of Chemical Pathology, Erasmus University Rotherham?] in Rotterdam .
Written in English


Edition Notes

Statementdoor Gerardus de Jong.
The Physical Object
Paginationv, 104
Number of Pages104
ID Numbers
Open LibraryOL20686955M

The syndrome affects the central and peripheral nervous system, and also the retina, liver, bone, adipose tissue, and genital organs. Abnormalities of glycoproteins, glycopeptide hormones, and lipids have been found in serum from these patients, the most pronounced being increased cathodal forms of by: Recombinant human transferrin as well as N- and C-terminal half-transferrins, produced in Escherichia coli, are deposited in inclusion bodies by the bacteria. The isolation and purification of the recombinant proteins from these inclusion bodies are described here. The amino acid compositions and N-terminal sequences of the proteins were determined, and found to be in .

Heterogeneous reactivity of human serum transferrin (Tf) with lectins was analysed using patient sera to determine whether it can be used to distinguish patients with hepatocellular carcinoma (HCC) from those with liver cirrhosis (LC). Microheterogeneity of Tf was analysed by crossed immunoaffinity electrophoresis (CIAE) with concanavalin A (Con A) and Lens culinaris . H G van Eijk's research works with 4, citations and 1, reads, including: N van Rijn, Ned Tschr Geneesk.

  The scheme of physiological significance of IRP1 in vivo. IRP1 is the predominant IRP protein in renal interstitial fibroblasts and pulmonary endothelial cells. In iron-replete conditions, IRP1 ligates an iron–sulfur cluster and displays cytosolic Cited by:   Jong G de. The physiological significance of transferrin microheterogeneity. Thesis, Medical Faculty, Erasmus University Rotterdam. Jong G de, Eijk HG van. Microheterogeneity of human serum transferrin: a biological phenomenon studied by isoelectric focusing in immobilized pH by: 6.


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Physiological significance of transferrin microheterogeneity by Gerardus de Jong Download PDF EPUB FB2

The physiological significance of transferrin microheterogeneity An interpretation of the role of N-linked glycans in transferrin and iron metabolism. De physiologische betekenis van de microheterogeniteit van transferrine Een interpretatie van de rol van eiwitgebonden oligosaccharides in transferrine-en ijzermetabolisrne.

ProefschriftCited by: 1. The physiological significance of transferrin microheterogeneity: an interpretation of the role of N-linked glycans in transferrin and iron metabolism / Author: G.

de Jong (Gerardus) Degree grantor: Erasmus MC: University Medical Center Rotterdam, Chemical Pathology: Supporting host: Erasmus MC: University Medical Center Rotterdam, Chemical Author: G.

deJong. Concerning the percentage of transferrin-iron complex, low iron-bound transferrin indicates low iron levels in the body, which affects hemoglobin and erythropoiesis. The significance of transferrin is that it can detect iron deficiency and can be used to monitor erythropoiesis.

The physiological significance of transferrin microheterogeneity: an interpretation of the role of N-linked glycans in transferrin and iron metabolism /Author: Gerardus Jong. The physiological significance of transferrin microheterogeneity: an interpretation of the role of N-linked glycans in transferrin and iron metabolism / By Author: G.

(Gerardus) de Jong. The physiological significance of transferrin microheterogeneity: an interpretation of the role of N-linked glycans in transferrin and iron metabolism /. Erasmus University Rotterdam. Erasmus University by: 1. Trypanosoma brucei is a parasite of mammals that causes sleeping sickness in man and Nagana in cattle.

The protozoan fulfills its iron requirement Cited by: Transferrin (Tf) is an iron-carrying plasma glycoprotein (– mg/dl) and plays an important physiological role in transporting iron from the sites of absorption and storage to the various cells in the human by: Comparative Biochemistry and Physiology Part A: Physiology, Vol.

No. 4 Transferrin receptors of rat and human brain and cerebral microvessels and their status in Alzheimer's disease Brain Research, Vol.

No. Cited by: Isoelectric focusing of iron saturated serum has been established as a convenient method for showing transferrin glycan microheterogeneity. In a clinical setting, the method is used in the detection of cerebrospinal fluid leakage, the screening for surreptitious alcohol abuse and in the diagnosis of the carbohydrate deficient glycoprotein by: Request PDF | Transferrin Microheterogeneity in Human Perilymph | Objectives/Hypothesis Assay for β2-(asialo-) transferrin has been advocated for use in.

Abstract. The heterogeneity of human serum transferrin and the possible functional significance of transferrin heterogeneity and microheterogeneity in biological systems (bone marrow, liver and placenta) is a topic in transferrin by: Interpreted in the respective pathophysiological contexts results show that: (1) N-linked glycosylation of transferrin is a strictly controlled process, both in the physiological states and in disease.

(2) Microheterogeneity is determined independently from transferrin Cited by: The discussion covers the genetic control of transferrin synthesis, its intracellular synthesis, intra-and extracellular transport, and its interaction with transferrin receptors. The role of transferrin in iron metabolism is evaluated, both with regard to iron uptake by transferrin as to iron uptake from transferrin by different by: Actade Jong G.

() The physiological significance of transferrin microheterogeneity. An interpretation of the role of N-linked glycans in transferrin by: Anderson NL, Anderson NG () Microheterogeneity of serum transferrin, haptoglobin and alpha2 HS glycoprotein by high resolution two-dimensional electrophoresis.

Biochem Biophys Res Commun – PubMed CrossRef Google ScholarCited by: 1. Explaines how the TIBC, UIBC, and transferrin tests are used, when TIBC, UIBC, and transferrin tests are ordered, and what the results of these tests might mean.

Total iron-binding capacity (TIBC) is most frequently used along with a serum iron test to evaluate people suspected of having either iron deficiency or iron overload.

The results suggest that the relative proportions of transferrin carbohydrate variants was unchanged when the concentration of transferrin was increased in serum from normal donors, whereas in the serum of pregnant women, especially in the last 3 months of pregnancy, when the serum concentration of transferrin reached g/l, the relative Cited by: Physiological significance of the marked increased branching of the glycans of human serotransferrin during pregnancy.

Human serotransferrin (Tf) presents a microheterogeneity based on the existence of biantennary and triantennary glycans of the N-acetyl-lactosaminic type.

by each of the three purified variants or by a mixture of these. Transferrin receptor in human placental brush border membranes. Studies on the binding of transferrin to placental membrane vesicles and the identification of a placental brush border glycoprotein with high affinity for by:.

Transferrin (Tf) is a glycoprotein responsible for iron transport in the human body. Physiologically in reaction with Concanavalin A, Tf occurs in four distinct variants Tf1, Tf2, Tf3 (apo-Tf) and by: 8.Transferrin, the unique plasma iron carrier, was discovered thirty years ago [1].

Human transferrin belongs to a class of proteins which assume the same physiological function. Though identical as to this function, human transferrin consists of at least twenty variants as shown off by electrophoretic studies.Transferrin is the most important physiological source of iron for red cells (Ponka, ).

The liver synthesizes transferrin and secretes it into the plasma. Transferrins are produced locally in the testes and CNS.